Systematic Review: Teknologi Needle Free Jet Injection Insulin (NFJI) Efektif Mengontrol Konsentrasi Glukosa Pada Penderita Diabetes Melitus Tipe 2

Rofi Syahrizal, Abu Bakar, Harmayetty Harmayetty, Anna Juwita Puspita Sari


Needle-free jet injection (NFJI) is a needleless method for insulin delivery in type 2 diabetes mellitus (T2DM) patients. This study evaluates NFJI's effectiveness in controlling blood glucose. In this study, we conducted a systematic review following the PRISMA guidelines, searching six databases (EBSCO Host, ProQuest, PubMed, ScienceDirect, Scopus, and Web of Science). The search yielded a total of 379 articles. We used the following keywords: "Jet injection," "Injection Ject," "Needle-Free Injection," "Insulin," "Diabetes Mellitus Type 2," "Diabetes Type 2," "Type 2 Diabetes," and "Blood Glucose" to identify relevant studies. The aim was to investigate the effectiveness of insulin jet NFJI in controlling blood glucose levels in T2DM patients. We assessed the risk of bias using the Joanna Briggs Institute (JBI) critical appraisal tools checklist. Out of the 379 articles identified, only seven met the inclusion criteria. Among these, six articles employed the Randomized Controlled Trial (RCT) method, while one article used a quasi-experimental design. Respondents in the study consisted of T2DM patients who were divided into two research groups: the intervention group and the control group. The results indicated a significant difference in blood glucose control values between the two groups. NFJI insulin method significantly improves glucose control. It offers advantages like painless, scar-free, low drug preparation, reusability, ease of use, and minimal disease transmission. Recommended for long-term T2DM treatment.



Blood Glucose, Diabetes Mellitus Type 2, Jet injection, Insulin.

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Al Ajlouni, M., Abujbara, M., Batieha, A., & Ajlouni, K. (2015). Prevalence of Lipohypertrophy and Associated Risk Factors in Insulin-Treated Patients With Type 2 Diabetes Mellitus. International Journal of Endocrinology and Metabolism, 13(2).

Blanco, M., Hernández, M. T., Strauss, K. W., & Amaya, M. (2013). Prevalence and risk factors of lipohypertrophy in insulin-injecting patients with diabetes. Diabetes & Metabolism, 39(5), 445–453.

de Wit, H. M., Engwerda, E. E. C., Tack, C. J., & de Galan, B. E. (2015). Insulin administered by needle-free jet injection corrects marked hyperglycaemia faster in overweight or obese patients with diabetes. Diabetes, Obesity and Metabolism, 17(11), 1093–1099.

Derraik, J. G. B., Rademaker, M., Cutfield, W. S., Pinto, T. E., Tregurtha, S., Faherty, A., Peart, J. M., Drury, P. L., & Hofman, P. L. (2014). Effects of Age, Gender, BMI, and Anatomical Site on Skin Thickness in Children and Adults with Diabetes. PLoS ONE, 9(1), e86637.

Dukare, M. V., & Saudagar, R. B. (2018). Needle-Free Injection System. International Journal of Current Pharmaceutical Research, 10(2), 17.

Engwerda, E. E. C., Tack, C. J., & de Galan, B. E. (2017). Pharmacokinetic and Pharmacodynamic Variability of Insulin When Administered by Jet Injection. Journal of Diabetes Science and Technology, 11(5), 947–952.

Engwerda, E. E. C., Tack, C. J., & De Galan, B. E. (2013). Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes. Diabetes Care, 36(11), 3436–3441.

Guo, L., Xiao, X., Sun, X., & Qi, C. (2017). Comparison of jet injector and insulin pen in controlling plasma glucose and insulin concentrations in type 2 diabetic patients. Medicine, 96(1), e5482.

Gupta, A. (2022). Structure and properties of insulin. In Understanding Insulin and

Insulin Resistance (pp. 29–70). Elsevier.

Hirsch, L. J., & Strauss, K. W. (2019). The Injection Technique Factor: What You Don’t Know or Teach Can Make a Difference. Clinical Diabetes, 37(3), 227–233.

Ji, J., & Lou, Q. (2014). Insulin pen injection technique survey in patients with type 2 diabetes in mainland China in 2010. Current Medical Research and Opinion, 30(6), 1087–1093.

Jin, X., Sun, Q., Yue, C., Han, J., Zhou, X., Guan, Q., & Zhang, X. (2023). A clinical observation study on the effect of needle-free insulin syringe on blood glucose control and well-being index in patients with early-onset type 2 diabetes mellitus. Frontiers in Endocrinology, 14(February), 1–7.

Joanna Briggs Institute. (2020). Checklist for randomized controlled trials - Critical Appraisal tools for use in JBI Systematic Reviews. Jbi, 1–5.

Kale, T. R., & Momin, M. (2014). Needle free injection technology - An overview. INNOVATIONS in Pharmacy, 5(1).

Kong, X., Luo, M., Cai, L., Zhang, P., Yan, R., Hu, Y., Li, H., & Ma, J. (2021). Needle-free jet injection of insulin glargine improves glycemic control in patients with type 2 diabetes mellitus: a study based on the flash glucose monitoring system. Expert Opinion on Drug Delivery, 18(5), 635–641.

Li, M., Huo, L., Du, F., Li, W., Zhang, H., & Shi, B. (2022). Prevalence, emotional and follow-up burden of insulin injection-related needle-stick injuries among clinical nurses in Shaanxi Province, west of China: A cross-sectional study. Nursing Open, 9(4), 1984–1994.

Meisenberg, G., & Simmons, W. H. (2017). Principles Of Medical Biochemistry (4th ed.). Elsevier.

Mohizin, A., & Kim, J. K. (2018). Current engineering and clinical aspects of needle-free injectors: A review. Journal of Mechanical Science and Technology, 32(12), 5737–5747.

Pan, Q., Zhang, L., Gu, A., Yu, D., Wang, X., Zhou, Y., & Guo, L. (2022). The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals. Frontiers in Endocrinology, 13.

Peyrot, M., Rubin, R. R., Kruger, D. F., & Travis, L. B. (2010). Correlates of insulin injection omission. Diabetes Care, 33(2), 240–245.

Pingle, P., Joshi, I., Sodhi, R. K., Madan, J., Mehra, N. K., Singh, P. K., Srivastava, S., Khatri, D. K., & Singh, S. B. (2022). Needle-free technology for biomedical applications. In Multifunctional Nanocarriers (pp. 149–173). Elsevier.

Rostini, T., & Rita, C. (2018). Mengenal Metode Elektroforesis. Indonesian Journal of Clinical Pathology and Medical Laboratory, 15(3), 87–90.

Santosa, A., & Rosa, E. M. (2014). Efektifivitas Lokasi Dan Waktu Injeksi Insulin Terhadap Pengendalian Kadar Gula Darah 2 Jam Setelah Makan Pada Penderita Diabetes Melitus. IJNP (Indonesian Journal of Nursing Practices), 1(2), 128–136.

Schlich, M., Casula, L., Musa, A., Pireddu, R., Pitzanti, G., Cardia, M. C., Valenti, D., Marceddu, S., Fadda, A. M., De Luca, M. A., Sinico, C., & Lai, F. (2022). Needle-Free Jet Injectors and Nanosuspensions: Exploring the Potential of an Unexpected Pair. Pharmaceutics, 14(5), 1085.

Sun, Y., Wang, J., Li, H., Sun, X., Su, X., & Ma, J. (2020). Comparison of glucose variability in patients with type 2 diabetes administrated glargine with needle-free jet injector and conventional insulin pen. Expert Opinion on Drug Delivery, 17(5), 713–717.

Tarantola, A., Abiteboul, D., & Rachline, A. (2006). Infection risks following accidental exposure to blood or body fluids in health care workers: A review of pathogens transmitted in published cases. American Journal of Infection Control, 34(6), 367–375.

Thakur Singh, R. R., Tekko, I., McAvoy, K., McMillan, H., Jones, D., & Donnelly, R. F. (2017). Minimally invasive microneedles for ocular drug delivery. Expert Opinion on Drug Delivery, 14(4), 525–537.

Wang, X. (2014). Vaccine and Needle-Free Vaccination Delivery System. Journal of Microbial & Biochemical Technology, 06(06), 359–360.

Weir, G. C., Gaglia, J., & Bonner-Weir, S. (2020). Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes. The Lancet Diabetes & Endocrinology, 8(3), 249–256.

Weniger, B. G., & Papania, M. J. (2012). Alternative vaccine delivery methods. In Vaccines: Sixth Edition (Sixth Edit, Issue January). Elsevier Inc.

Xing, Y., Xie, X., Xu, J., Liu, J., He, Q., Yang, W., Zhang, N., Li, X., Wang, L., Fu, J., Zhou, J., Gao, B., Ming, J., Liu, X., Lai, J., Liu, T., Shi, M., & Ji, Q. (2019). Efficacy and safety of a needle-free injector in Chinese patients with type 2 diabetes mellitus treated with basal insulin: a multicentre, prospective, randomised, crossover study. Expert Opinion on Drug Delivery, 16(9), 995–1002.

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