Ekstrak Jahe (Zingiber Officinale Roscoe) Berpengaruh Terhadap Kepadatan Serabut Kolagen Luka Insisi

Idola Perdana Sulistyoning Suharto, Arif Nurma Etika

Abstract


Wound is a condition of damage to the anatomical structure of the skin causing skin disorders (Moenadjat, 2003). There are three phases in the wound healing process. These phases are the inflammatory, proliferative and maturation phases. Ginger has several active substances. The several active substances contained in ginger, namely triterpenoids, flavonoids and saponins. Flavonoid compounds has a role in activating macrophages. Saponins are able to activate TGF-β signals. The aim of this research was to analyze the effect of ginger extract to the density of collagen fibers in rats (Rattus norvegicus) with incision wounds. This study was an experimental research laboratory, with a post-test only control group design. Rats were divided into two major groups: control group (KK) who were given only the solvent CMC 1% and the treatment group (KP) were given orally at a dose of ginger extract 1 g / kg. Rat tissue will be observed on days 1, 5 and 10. Data were analyzed by one-way ANOVA test with p value 0.125. The conclusion of this study is there was no significant difference in collagen density between the control and treatment groups. Based on the results of this study it can be concluded that the giving of ginger (Zingiber officinale roscoe) can increase the density of incisional collagen even though it has insignificant differences

Keywords


collagen density; ginger extract; incisional wound

Full Text:

PDF

References


Aurelia. (2006). Pengaruh Pemberian Rebusan Daging Buah Mahkota Dewa (Phaleria macrocarpa) terhadap Aktivitas Fagositosis Makrofag pada Mencit Balb/c yang Diinfeksi Salmonella typhimurium. Universitas Diponegoro Semarang.

Charles HM Thorne MD, Geoffrey C. Gurtner MD, Kevin Chung, Arun Gosain, Babak Mehrara, Peter Rubin, S. L. S. M. F. (2016). Grabb and Smith’s Plastic Surgery. Philadelphia: Lippincott.

Etika, A. N., Nurrahayu, K. I., & Suharto, I. P. S. (2017). Pengaruh Ekstrak Jahe ( Zingiber Officinale Roscoe ) Terhadap Jumlah Sel Fibroblas Pada Tikus( Rattus Norvegicus ). Journal of Nursing Care & Biomolecular, 2(1), 10–14.

Kanzaki, T., Morisaki, N., Shiina, R., & Saito, Y. (1998). Role of transforming growth factor- b pathway in the mechanism of wound healing by saponin from Ginseng Radix rubra. British Journal of Pharmacology, 125, 255–262.

Keller, U. auf dem, Kümin, A., Braun, S., & Werner, S. (2006). Reactive Oxygen Species and Their Detoxification in Healing Skin Wounds. Journal of Investigative Dermatology Symposium Proceedings, 11, 106–111. https://doi.org/10.1038/sj.jidsymp.5650001

Kurahashi, T., & Fujii, J. (2015). Roles of Antioxidative Enzymes in Wound Healing. Journal of Developmental Biology, 3, 57–70. https://doi.org/10.3390/jdb3020057

Mackay, D., & Miller, A. L. (2016). Nutritional_support_for_wound_.PDF. Wound Healing, 8(December 2003), 359–377.

Mani, R., & Teot, L. (2011). The Basic Needs to Achieve Wound Healing. New delhi: Jaypee Brothers Medical.

Moenadjat, Y. (2003). Luka Bakar Pengetahuan Klinis dan Praktis. Jakarta: FKUI.

Novriansyah, R. (2008). Perbedaan Kepadatan Kolagen Di Sekitar Luka Insisi Tikus Wistar yang Dibalut Kasa Knvensional dan Penutup Oklusif Hidrokoloid Selama 2 dan 14 Hari. Diponegoro.

Rachmawati, N. dkk. (2006). Re-Epitelisasi,Kepadatan Fibroblast Dan Serabut Kolagen Pada Proses Penyembuhan Luka Gingiva Labial Tikus Sprague dawley Setelah Pemberian Topikal Ekstrak Buah Adas (Foeniculum vulgare Mill.) 50%.

Smeltzer, suzanne c., & Bare, brenda g. (2010). Keperawatan Medikal Bedah. Jakarta: EGC.

Suharto, I. P. S. (2015). Efek Pemberian Ekstrak Daging Buah Mahkota Dewa (Phaleria macrocarpa ) terhadap Jumlah Sel Neutrofil Luka Insisi pada Tikus Putih ( Rattus norvegicus ). Care, 3(3), 19–29.

Widjhati, R. (2009). Efek Samping Obat Herbal. Retrieved February 2, 2014, from http://www.indospiritual.com




DOI: http://dx.doi.org/10.33366/jc.v7i1.1106

Article metrics

Abstract views : 343 | views : 233

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Care : Jurnal Ilmiah Ilmu Kesehatan

Creative Commons License
Care :Jurnal Ilmiah Ilmu kesehatan by https://jurnal.unitri.ac.id/index.php/care is licensed under a Creative Commons Attribution 4.0 International License.

View My Stats